Endocrine Abstracts

Background: Thyrotoxicosis is one of the commonest endocrine disorders and its severe form can manifest as thyroid storm in acute setting leading to organ dysfunctions including heart failure. Cases: 1: A 58-year-old female with a significant past medical history of MI, paroxysmal AF/atrial flutter, and hyperthyroidism presented with a one-week history of palpitations, plethora, diaphoresis, heat intolerance, loose stools, and a TSH <0.01; Free T4-33...

The introduction of immune checkpoint inhibitors (ICIs) in clinical management of cancer has had an undeniable impact in management of cancer patients. Currently there are several ICIs are used across Europe including but not limited to, pembrolizumab, atezolizumab, and ipilimumab. Even though their clinical efficacy is reputable, they have the potential of causing serious immunotherapy-related adverse events’ (irADRs) in several organ systems including endocrine organs. ...